Pharmaceutical firm Boehringer Ingelheim has reported that the company’s Orphan Drug nintedanib has been found “safe and effective” for patients with malignant pleural mesothelioma (MPM). In a clinical trial known as LUME-Meso trial a promising 44 of 87 patients treated with nintedanib showed improved progression free survival (PFS) and a trend for prolonged overall survival (OS). The greatest benefit was experienced by patients with epithelioid MPM, which is the most common and treatable subtype of mesothelioma. These patients showed a PFS of 9.7 months vs. 5.7 months and OS of 20.6 months vs. 15.2 months.
This study also showed that just 6.8% of adverse events in patients treated with nintedanib led to treatment discontinuation.
Nintedanib “is an oral triple angiokinase inhibitor which simultaneously inhibits vascular endothelial growth factor receptors (VEGFR 1-3), platelet-derived growth factor receptors (PDGFR) and fibroblast growth factor receptors (FGFR 1-3) signalling pathways,” Boehringer Ingelheim. “These three different angiokinase receptors, which are not yet targeted by any currently available therapies, play an important role not only in angiogenesis but also in tumor growth and the development of metastases.”
The findings of the study were announced at the International Association for the Study of Lung Cancer (IASLC) Multidisciplinary Symposium in Thoracic Oncology.
Though there is no cure for mesothelioma, the success of nintedanib is just one example of how far treatment options have come in just the last seven years. The result is more mesothelioma patients are living longer and more productive lives after diagnosis.
If you have been diagnosed with mesothelioma, ask your doctor about clinical trials such as the LUME-Meso trial. This and many other clinical trials are now recruiting at dozens of hospitals and research centers across the U.S. Talk to your doctor today.
Sources
Grosso, F., N. Steele, S. Popat, and J. Barrueco. "Nintedanib Plus Pemetrexed/Cisplatin in Patients With Malignant Pleural Mesothelioma: Phase II Results From the Randomized, Placebo-Controlled LUME-Meso Trial." Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. U.S. National Library of Medicine, 11 Sept. 2017. Web. 28 Oct. 2017.
"Nintedanib (BIBF 1120) in Mesothelioma." ClinicalTrials.gov. U.S. National Library of Medicine, 19 Oct. 2017. Web. 30 Oct. 2017.
"Nintedanib Granted Orphan Drug Designation for Treatment of Mesothelioma." Boehringer Ingelheim, 2016. Web. 28 Oct. 2017.
"Nintedanib Shows Promise for Malignant Pleural Mesothelioma." HemOnc Today, 16 Sept. 2017. Web. 28
