Memorial Sloan Kettering Cancer Center Says 10 Clinical Trials for Mesothelioma Underway

Memorial Sloan Kettering Cancer Center (MSK) is constantly testing new ways to fight mesothelioma. The Center says it is often “the first to be aware of the latest scientific discoveries and medical advances for the disease,” so patients “often have access to clinical trials of new treatment options that are not available in most other hospitals.” MSK has announced that at least 10 such clinical trials are currently underway and recruiting participants. They include:

1. A Phase I Study of Immunotherapy with Genetically Engineered T Cells (CAR T Cells) to Treat Mesothelioma and Malignant Pleural Disease from Lung and Breast Cancers
2. A Phase I Study of LY3023414 in Patients with Advanced Cancer
3. A Phase I Study of Immunotherapy with Emactuzumab and RO7009789 in Patients with Advanced Solid Tumors
4. Phase I Study of PF-02341066 in People with Advanced Cancer
5. A Phase II Study of BIBF 1120 (Nintedanib) for Recurrent Malignant Pleural Mesothelioma
6. A Phase II Study of Nintedanib plus Prednisone to Treat Radiation Pneumonitis
7. A Phase II/III Study of Chemotherapy with or without ADI-PEG 20 in Patients with Malignant Pleural Mesothelioma
8. A Phase III Study of Immunotherapy versus Chemotherapy to Treat Inoperable Pleural Mesothelioma
9. A Study of Pevonedistat Alone and in Combination with Chemotherapy in Patients with Mesothelioma
10. A Study of Stereotactic Body Radiation Therapy and Avelumab Immunotherapy to Treat Malignant Mesothelioma

 

“These research studies evaluate the safety and effectiveness of new ways to diagnose and treat mesothelioma,” says MSK. They could also give treatment teams information about current plans of care.

Tumor vaccines, antibody therapies, T cell–based treatments, molecularly targeted medications, and the use of anticancer viruses are just a few promising approaches that MSK has explored so far.

Mesothelioma takes decades to cause any noticeable symptoms, so the disease is often diagnosed at an advanced stage. This leads to fewer treatment options and a poorer prognosis. The Center says that as an MSK patient, regardless of the stage of your disease, there will likely be a clinical trial option for you. This is often the case at most major cancer treatment centers around the world. At any given time, these facilities typically have hundreds of clinical trials underway for most cancer diagnoses and stages of disease.

If you have been diagnosed with mesothelioma, talk to your doctor about participating in a clinical trial. Clinical trials offer the opportunity to try new and developing drugs that have the potential to extend or save your life. Talk to your doctor today.

 

Sources 

"Mesothelioma Clinical Trials & Research." MSKCC.org. Memorial Sloan Kettering Cancer Center (MSK), 2018. Web. 26 Mar. 2018.